Article

Nucleosome-CHD4 chromatin remodeller structure explains human disease mutations

2019-06-24

Abstract excerpt

Chromatin remodelling plays important roles in gene regulation during development, differentiation and in disease. The chromatin remodelling enzyme CHD4 is a component of the NuRD and ChAHP complexes that are involved in gene repression. Here we report the cryo-electron microscopy (cryo-EM) structure of Homo sapiens CHD4 engaged with a nucleosome core particle in the presence of the non-hydrolysable ATP analogue...

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Literature Corpus work: 86a45ebf-a2da-5458-8655-a1384e492549
DOI: 10.1101/665562

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