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Article

A Novel N-terminal Region to Chromodomain in CHD7 is Required for the Efficient Remodeling Activity.

Journal of molecular biology - 3 Sept 2021

Lee Eunhye, Kang Chanshin, Purhonen Pasi, Hebert Hans, Bouazoune Karim, Hohng Sungchul, Song Ji-Joon

Abstract excerpt

Chromodomain-Helicase DNA binding protein 7 (CHD7) is an ATP dependent chromatin remodeler involved in maintaining open chromatin structure. Mutations of CHD7 gene causes multiple developmental disorders, notably CHARGE syndrome. However, there is not much known about the molecular mechanism by which CHD7 remodels nucleosomes. Here, we performed biochemical and biophysical analysis on CHD7 chromatin remodeler and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 34161779
DOI: 10.1016/j.jmb.2021.167114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A Novel N-terminal Region to Chromodomain in CHD7 is Required for the Efficient Remodeling Activity.PMID 34161779Read ↗

CHD7 interacts with the nucleosome acidic patch for its efficient activity via its N-terminal regionSemantic proximity Read ↗

Functional Insights into Chromatin Remodelling from Studies on CHARGE Syndrome.Semantic proximity Read ↗

Chromatin remodeling by the CHD7 protein is impaired by mutations that cause human developmental disordersSemantic proximity Read ↗

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CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaksSemantic proximity Read ↗

Chromodomain proteins in development: lessons from CHARGE syndromeSemantic proximity Read ↗

Mutation update on the CHD7 gene involved in CHARGE syndrome.Semantic proximity Read ↗

CHD7 regulates cardiovascular development through ATP-dependent and -independent activities.Semantic proximity Read ↗

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Chromatin remodeling by the CHD7 protein is impaired by mutations that cause human developmental disordersSemantic proximity Read ↗

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