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Article

Functional Insights into Chromatin Remodelling from Studies on CHARGE Syndrome.

Trends in genetics : TIG - 1 Oct 2015

Basson M Albert, van Ravenswaaij-Arts Conny

Abstract excerpt

CHARGE syndrome is a rare genetic syndrome characterised by a unique combination of multiple organ anomalies. Dominant loss-of-function mutations in the gene encoding chromodomain helicase DNA binding protein 7 (CHD7), which is an ATP-dependent chromatin remodeller, have been identified as the cause of CHARGE syndrome. Here, we review recent work aimed at understanding the mechanism of CHD7 function in normal and...

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Share to CHD7 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Assembly and Disassembly

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Share to Gene Expression Regulation, Developmental

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Source

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Identifiers

PMID: 26411921
DOI: 10.1016/j.tig.2015.05.009
PMCID: PMC4604214

Genes

CHD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Functional Insights into Chromatin Remodelling from Studies on CHARGE Syndrome.PMID 26411921Read ↗

Chromodomain proteins in development: lessons from CHARGE syndromeSemantic proximity Read ↗

Versatile Roles of the Chromatin Remodeler CHD7 during Brain Development and DiseaseSemantic proximity Read ↗

Mutation update on the CHD7 gene involved in CHARGE syndrome.Semantic proximity Read ↗

Multi-omic analyses identify molecular targets of Chd7 that contribute to CHARGE syndrome model phenotypes.Semantic proximity Read ↗

Chromatin remodeling by the CHD7 protein is impaired by mutations that cause human developmental disordersSemantic proximity Read ↗

Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programmeSemantic proximity Read ↗

Multi-omic analyses identify molecular targets of Chd7 that mediate CHARGE syndrome model phenotypesSemantic proximity Read ↗

Genetic analysis of CHARGE syndrome identifies overlapping molecular biology.Semantic proximity Read ↗

A Novel N-terminal Region to Chromodomain in CHD7 is Required for the Efficient Remodeling Activity.Semantic proximity Read ↗

CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaksSemantic proximity Read ↗

CHD7 Targets Active Gene Enhancer Elements to Modulate ES Cell-Specific Gene ExpressionSemantic proximity Read ↗

Molecular and phenotypic aspects of CHD7 mutation in CHARGE syndrome.Semantic proximity Read ↗

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