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Article

Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations.

eLife - 16 Jun 2020

Farnung Lucas, Ochmann Moritz, Cramer Patrick

Abstract excerpt

Chromatin remodeling plays important roles in gene regulation during development, differentiation and in disease. The chromatin remodeling enzyme CHD4 is a component of the NuRD and ChAHP complexes that are involved in gene repression. Here, we report the cryo-electron microscopy (cryo-EM) structure of Homo sapiens CHD4 engaged with a nucleosome core particle in the presence of the non-hydrolysable ATP analogue...

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Chromatin Assembly and Disassembly
Cryoelectron Microscopy
Mutation
Nucleosomes
Xenopus laevis

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PMID: 32543371
DOI: 10.7554/eLife.56178
PMCID: PMC7338049

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