Article
Binding of regulatory proteins to nucleosomes is modulated by dynamic histone tails
2020-10-30
Abstract excerpt
Despite histone tails’ critical roles in epigenetic regulation, little is known about mechanisms of how histone tails modulate the nucleosomal DNA solvent accessibility and recognition of nucleosomes by other macromolecules. Here we generate extensive atomic level conformational ensembles of histone tails in the context of the full human nucleosome, totaling 26 microseconds of molecular dynamics simulations. We ex...
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Identifiers and source
- Literature Corpus work
- 52528680-454a-5b60-9e0a-f69e1492f3b9
- DOI
- 10.1101/2020.10.30.360990