Article

Proliferative History Is a Novel Driver of Clinical Outcome in Splenic Marginal Zone Lymphoma

2024-01-17

Abstract excerpt

The epiCMIT (epigenetically-determined Cumulative MIToses) mitotic clock traces B-cell mitotic history via DNA methylation changes in heterochromatin and H3K27me3-containing chromatin. While high scores correlated with poor outcomes in CLL and MCL, its prognostic significance in SMZL remains unknown. Derived from 142 SMZL cases using DNA methylation microarrays, epiCMIT values were correlated with genomic, transcr...

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Literature Corpus work: 0900e244-0367-5998-a8b3-d5f196473dee
DOI: 10.1101/2024.01.16.24301320

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