DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia.

doi:10.1038/ng.3488

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Article

DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia.

Nature genetics - 1 Mar 2016

Oakes Christopher C, Seifert Marc, Assenov Yassen, Gu Lei, Przekopowitz Martina, Ruppert Amy S, Wang Qi, Imbusch Charles D, Serva Andrius, Koser Sandra D, Brocks David, Lipka Daniel B, Bogatyrova Olga, Weichenhan Dieter, Brors Benedikt, Rassenti Laura, Kipps Thomas J, Mertens Daniel, Zapatka Marc, Lichter Peter, Döhner Hartmut, Küppers Ralf, Zenz Thorsten, Stilgenbauer Stephan, Byrd John C, Plass Christoph

Abstract excerpt

Charting differences between tumors and normal tissue is a mainstay of cancer research. However, clonal tumor expansion from complex normal tissue architectures potentially obscures cancer-specific events, including divergent epigenetic patterns. Using whole-genome bisulfite sequencing of normal B cell subsets, we observed broad epigenetic programming of selective transcription factor binding sites coincident...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26780610
DOI: 10.1038/ng.3488
PMCID: PMC4963005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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