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Article

Ig Enhancers Increase RNA Polymerase II Stalling at Somatic Hypermutation Target Sequences.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2022

Tarsalainen Alina, Maman Yaakov, Meng Fei-Long, Kyläniemi Minna K, Soikkeli Anni, Budzyńska Paulina, McDonald Jessica J, Šenigl Filip, Alt Frederic W, Schatz David G, Alinikula Jukka

Abstract excerpt

Somatic hypermutation (SHM) drives the genetic diversity of Ig genes in activated B cells and supports the generation of Abs with increased affinity for Ag. SHM is targeted to Ig genes by their enhancers (diversification activators [DIVACs]), but how the enhancers mediate this activity is unknown. We show using chicken DT40 B cells that highly active DIVACs increase the phosphorylation of RNA polymerase II (Pol...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34862258
DOI: 10.4049/jimmunol.2100923
PMCID: PMC8702490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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