Article
Modelling the dual role of Per phosphorylation and its effect on the period and phase of the mammalian circadian clock.
IET systems biology - 1 Jan 2011
Leloup J-C, Goldbeter A
Abstract excerpt
Circadian clocks are regulated at the post-translational level by a variety of processes among which protein phosphorylation plays a prominent, although complex, role. Thus, the phosphorylation of different sites on the clock protein PER by casein kinase I (CKI) can lead to opposite effects on the stability of the protein and on the period of circadian oscillations. Here the authors extend a computational model...
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