Modelling the dual role of Per phosphorylation and its effect on the period and phase of the mammalian circadian clock.

doi:10.1049/iet-syb.2009.0068

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Article

Modelling the dual role of Per phosphorylation and its effect on the period and phase of the mammalian circadian clock.

IET systems biology - 1 Jan 2011

Leloup J-C, Goldbeter A

Abstract excerpt

Circadian clocks are regulated at the post-translational level by a variety of processes among which protein phosphorylation plays a prominent, although complex, role. Thus, the phosphorylation of different sites on the clock protein PER by casein kinase I (CKI) can lead to opposite effects on th...

Topics

Animals
Circadian Clocks
Circadian Rhythm
Glycogen Synthase Kinase 3
Mutation
Period Circadian Proteins
Phosphorylation
Transcription Factors

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