Article

Lipid-rich ascites reprograms T cell lipid metabolic transcriptome to drive dysfunction

2026-03-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> Bispecific T cell engagers (BiTEs) have recently been approved as a locoregional immunotherapy for malignant ascites. Although ascites is recognised as a lipid-rich, immunosuppressive environment, the mechanisms by which ascites, particularly its lipid components, suppress antitumour immunity remain poorly understood. Here, we investigated the impact of ascites-associated lipid...

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Literature Corpus work: 2adea047-e586-529e-82b4-8e4c4b482dc1
DOI: 10.64898/2026.03.11.711101

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