Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity.

doi:10.1038/s41590-021-01047-4

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Article

Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity.

Nature immunology - 1 Nov 2021

Di Conza Giusy, Tsai Chin-Hsien, Gallart-Ayala Hector, Yu Yi-Ru, Franco Fabien, Zaffalon Lea, Xie Xin, Li Xiaoyun, Xiao Zhengtao, Raines Lydia N, Falquet Maryline, Jalil Antoine, Locasale Jason W, Percipalle Piergiorgio, Masson David, Huang Stanley Ching-Cheng, Martinon Fabio, Ivanisevic Julijana, Ho Ping-Chih

Abstract excerpt

Tumor-associated macrophages (TAMs) display pro-tumorigenic phenotypes for supporting tumor progression in response to microenvironmental cues imposed by tumor and stromal cells. However, the underlying mechanisms by which tumor cells instruct TAM behavior remain elusive. Here, we uncover that tumor-cell-derived glucosylceramide stimulated unconventional endoplasmic reticulum (ER) stress responses by inducing...

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PMID: 34686867
DOI: 10.1038/s41590-021-01047-4
PMCID: PMC7611917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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