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Article

Pan-cancer analysis of cholesterol metabolism reveals the uptake as a modulator of tumor immune features and of the KRAS pathway.

Cellular oncology (Dordrecht, Netherlands) - 12 Feb 2026

Machado Ana Luísa, Pinto Ana, Carvalho Joana, Fernandes Verónica, Pereira Luísa, Roelands Jessica, Gonçalves Jorge, Miranda N F C C, Oliveira Maria José, Velho Sérgia

Abstract excerpt

PURPOSE: Cholesterol dysregulation plays a central role in tumor progression and has emerged as a potential therapeutic target. Its dysregulation within the tumor microenvironment is increasingly considered a strong modifier of multiple cancer traits. Targeting cholesterol, particularly its biosynthetic pathway, has been explored to enhance therapy, yet outcomes remain inconsistent, likely reflecting a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41677991
DOI: 10.1007/s13402-026-01171-z
PMCID: PMC12901284

Genes

KRAS
CD4
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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