Article

Malignant ascites enhance γδ T cell cytotoxicity towards ovarian cancer via modulating chemokines secretion from the cancer cells that recruits γδ T cells

2025-03-11

Abstract excerpt

Ovarian cancer patients usually develops peritoneal metastasis and malignant ascites in the advanced stages, which form immuno-suppressive tumor microenvironments that limit the efficacy of immuno-therapies. However, during our previous research trying to develop a γδ T cell-based cell therapy, we noticed that the malignant ascites may enhance the cytotoxicity of γδ T cells towards ovarian cancer cells. Herein, in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e63c61b7-65f9-550a-b4d3-0b33ae440052
DOI: 10.1101/2025.03.05.641778

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Malignant ascites enhance γδ T cell cytotoxicity towards ovarian cancer via modulating chemokines secretion from the cancer cells that recruits γδ T cellsDOI 10.1101/2025.03.05.641778Read

Preliminary Exploration of the Relationship between Tumor Microenvironment in Malignant Ascites and Patient PrognosisSemantic proximity Read

CXCL13 Correlates with Prognosis, Immune Infiltration, and T Cell Exhaustion in Ovarian CancerSemantic proximity Read

Lipid-rich ascites reprograms T cell lipid metabolic transcriptome to drive dysfunctionSemantic proximity Read

Integrated immuno-transcriptomic analysis of ovarian cancer identifies a four-chemokine-dominated subtype with antitumor immune-active phenotype and favorable prognosis.Semantic proximity Read

The role of CD8+ T-cells in colorectal cancer immunotherapySemantic proximity Read

Proteotranscriptomics Reveal Signaling Networks in the Ovarian Cancer MicroenvironmentSemantic proximity Read

Ovarian cancer cell cluster inhibits pancreatic cancer progressionSemantic proximity Read

Exhausted CD8⁺ T Cells Promote Ovarian Cancer Immunosuppression via CCL3-Driven M2 Macrophage PolarizationSemantic proximity Read

Role of γδ T Cells in Cancer Progression and Therapy.Semantic proximity Read

HO-3867 mediated modulation of Extracellular vesicles and Tumor microenvironment: A novel immunotherapeutic strategy for ovarian cancerSemantic proximity Read

Interferon-γ secreted by recruited Th1 cells in peritoneal cavity inhibits the formation of malignant ascitesSemantic proximity Read

Neutrophil extracellular trap formation correlates with improved overall survival in ovarian cancerSemantic proximity Read