Article

Genome-wide Analysis of Differential Transcriptional and Epigenetic Variability Across Human Immune Cell Types

2016-10-25

Abstract excerpt

<h4>Background</h4> A healthy immune system requires immune cells that adapt rapidly to environmental challenges. This phenotypic plasticity can be mediated by transcriptional and epigenetic variability. <h4>Results</h4> We applied a novel analytical approach to measure and compare transcriptional and epigenetic variability genome-wide across CD14 + CD16 − monocytes, CD66b + CD16 + neutrophils, and CD4 + CD...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fd85a63d-ca4a-54de-b9b4-b9f613174975
DOI: 10.1101/083246

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide Analysis of Differential Transcriptional and Epigenetic Variability Across Human Immune Cell TypesDOI 10.1101/083246Read

Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types.Semantic proximity Read

Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells.Semantic proximity Read

Comparative analysis of neutrophil and monocyte epigenomesSemantic proximity Read

Genome-wide DNA methylation map of human neutrophils reveals widespread inter-individual epigenetic variation.Semantic proximity Read

Single-cell analysis reveals the range of transcriptional states of circulating human neutrophilsSemantic proximity Read

A meta-analysis of immune cell fractions at high resolution reveals novel associations with common phenotypes and health outcomesSemantic proximity Read

Human and murine neutrophils share core transcriptional programs in both homeostatic and inflamed contextsSemantic proximity Read

Genetic variation in correlated regulatory regions of immunitySemantic proximity Read

Genomic modulators of gene expression in human neutrophils.Semantic proximity Read

Epigenomic and functional dynamics of human bone marrow myeloid differentiation to mature blood neutrophilsSemantic proximity Read

Epigenetic signature of human immune aging: the GESTALT studySemantic proximity Read

Using genetic and genomic approaches to understand haematopoietic cellular biology and dysregulation in diseaseSemantic proximity Read