Genome-wide analysis of the genetic regulation of gene expression in human neutrophils.

doi:10.1038/ncomms8971

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genome-wide analysis of the genetic regulation of gene expression in human neutrophils.

Nature communications - 10 Aug 2015

Andiappan Anand Kumar, Melchiotti Rossella, Poh Tuang Yeow, Nah Michelle, Puan Kia Joo, Vigano Elena, Haase Doreen, Yusof Nurhashikin, San Luis Boris, Lum Josephine, Kumar Dilip, Foo Shihui, Zhuang Li, Vasudev Anusha, Irwanto Astrid, Lee Bernett, Nardin Alessandra, Liu Hong, Zhang Furen, Connolly John, Liu Jianjun, Mortellaro Alessandra, Wang De Yun, Poidinger Michael, Larbi Anis, Zolezzi Francesca, Rotzschke Olaf

Abstract excerpt

Neutrophils are an abundant immune cell type involved in both antimicrobial defence and autoimmunity. The regulation of their gene expression, however, is still largely unknown. Here we report an eQTL study on isolated neutrophils from 114 healthy individuals of Chinese ethnicity, identifying 21,210 eQTLs on 832 unique genes. Unsupervised clustering analysis of these eQTLs confirms their role in inflammatory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cluster Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Genetic Linkage

Share to Genome-Wide Association Study

Share to Inflammation

Share to Neutrophils

Share to Quantitative Trait Loci

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 26259071
DOI: 10.1038/ncomms8971
PMCID: PMC4918343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide analysis of the genetic regulation of gene expression in human neutrophils.PMID 26259071Read ↗

Genomic modulators of gene expression in human neutrophils.Semantic proximity Read ↗

A comprehensive phenome wide analysis of the role of neutrophils in health and diseaseSemantic proximity Read ↗

Cell Specific eQTL Analysis without Sorting Cells.Semantic proximity Read ↗

CXCL5 gene polymorphisms are related to systemic concentrations and leukocyte production of epithelial neutrophil-activating peptide (ENA-78).Semantic proximity Read ↗

Multi-trait genetic analysis of asthma and eosinophils uncovers pleiotropic loci in East AsiansSemantic proximity Read ↗

Using genetic and genomic approaches to understand haematopoietic cellular biology and dysregulation in diseaseSemantic proximity Read ↗

Gene-Based Variant Analysis of Whole-Exome Sequencing in Relation to Eosinophil Count.Semantic proximity Read ↗

Multi-Trait Genetic Analysis of Asthma and Eosinophils Uncovers Novel Loci in East AsiansSemantic proximity Read ↗

Single-Cell Transcriptome Analysis of Peripheral Neutrophils From Patients With Idiopathic Pulmonary Arterial Hypertension.Semantic proximity Read ↗

Cell specific eQTL analysis without sorting cellsSemantic proximity Read ↗

Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated DiseasesSemantic proximity Read ↗

Age, Sex, and Genetics Influence the Abundance of Infiltrating Immune Cells in Human TissuesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.