Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci.

Genome research - 1 Jul 2013

Paul Dirk S, Albers Cornelis A, Rendon Augusto, Voss Katrin, Stephens Jonathan, van der Harst Pim, Chambers John C, Soranzo Nicole, Ouwehand Willem H, Deloukas Panos

Abstract excerpt

Nearly three-quarters of the 143 genetic signals associated with platelet and erythrocyte phenotypes identified by meta-analyses of genome-wide association (GWA) studies are located at non-protein-coding regions. Here, we assessed the role of candidate regulatory variants associated with cell type-restricted, closely related hematological quantitative traits in biologically relevant hematopoietic cell types. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Platelets
Share to Cell Lineage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Assembly and Disassembly

Share to Erythrocytes

Share to Myeloid Cells

Share to Nucleosomes

Share to Organ Specificity

Share to Regulatory Sequences, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 23570689
DOI: 10.1101/gr.155127.113
PMCID: PMC3698506

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci.PMID 23570689Read ↗

Maps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits.Semantic proximity Read ↗

find-tfbs: a tool to identify functional non-coding variants associated with complex human traits using open chromatin maps and phased whole-genome sequencesSemantic proximity Read ↗

Joint analysis of functional genomic data and genome-wide association studies of 18 human traitsSemantic proximity Read ↗

Seventy-five genetic loci influencing the human red blood cell.Semantic proximity Read ↗

Transcription factor networks disproportionately enrich for heritability of blood cell phenotypesSemantic proximity Read ↗

Joint analysis of functional genomic data and genome-wide association studies of 18 human traits.Semantic proximity Read ↗

Interrogation of human hematopoiesis at single-cell and single-variant resolutionSemantic proximity Read ↗

A large-scale transcriptome-wide association study (TWAS) of ten blood cell phenotypes reveals complexities of TWAS fine-mappingSemantic proximity Read ↗

The Polygenic and Monogenic Basis of Blood Traits and DiseasesSemantic proximity Read ↗

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms.Semantic proximity Read ↗

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters.Semantic proximity Read ↗

From GWAS Variant to Function: a Study of ~148,000 Variants for Blood Cell TraitsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.