Article

Human and murine neutrophils share core transcriptional programs in both homeostatic and inflamed contexts

2022-11-16

Abstract excerpt

Neutrophils are frequently studied in murine models, but the extent to which findings translate to humans remains poorly defined. Here, we performed an integrative transcriptomic analysis of 11 murine and 13 human datasets. In homeostasis, neutrophils exhibited the highest number of lineage-specific genes and the greatest degree of correlated expression among genes with one-to-one orthologs ( r = 0.79, P < 2.2 ×...

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Literature Corpus work: 43c1b95a-6b20-5cd1-a1c8-f03a71160db6
DOI: 10.1101/2022.11.13.516246

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