Article
Genomic modulators of gene expression in human neutrophils.
Nature communications - 7 Jul 2015
Naranbhai Vivek, Fairfax Benjamin P, Makino Seiko, Humburg Peter, Wong Daniel, Ng Esther, Hill Adrian V S, Knight Julian C
Abstract excerpt
Neutrophils form the most abundant leukocyte subset and are central to many disease processes. Technical challenges in transcriptomic profiling have prohibited genomic approaches to date. Here we map expression quantitative trait loci (eQTL) in peripheral blood CD16+ neutrophils from 101 healthy European adults. We identify cis-eQTL for 3281 neutrophil-expressed genes including many implicated in neutrophil...
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