Article

Reconstructing the history of polygenic scores using coalescent trees

2018-08-10

Abstract excerpt

1 Genome-wide association studies (GWAS) have revealed that many traits are highly polygenic, in that their within-population variance is governed in part by small-effect variants at many genetic loci. Standard population-genetic methods for inferring evolutionary history are ill-suited for polygenic traits—when there are many variants of small effect, signatures of natural selection are spread across the genome a...

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Literature Corpus work: c03a4797-e7f6-5359-8e8e-08bb8e79f29f
DOI: 10.1101/389221

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