Article

MT5-MMP C-terminal mutations reduce C99 and Aβ accumulation: A foundation for peptide-based Alzheimer’s interventions

2025-05-23

Abstract excerpt

<h4>ABSTRACT</h4> Our prior work established a pivotal role for membrane-type 5-matrix metalloproteinase (MT5-MMP) in Alzheimer’s disease (AD) pathogenesis, particularly through its C-terminal transmembrane (TM) and intracellular (IC) domains, which influence the fate of major toxic metabolites of toxic amyloid precursor protein (APP) metabolites, particularly C99 and Aβ. Hypothesizing that modifications in these...

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Literature Corpus work: 2ab73767-8acd-50b5-9199-d42b3d4310b9
DOI: 10.1101/2025.05.22.655451

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