Article

Midkine Attenuates Aβ Fibril Assembly and Amyloid Plaque Formation

2024-06-07

Abstract excerpt

<title>Abstract</title> <p>Proteomic profiling of Alzheimer's disease (AD) brains has identified numerous understudied proteins, including midkine (MDK), that are highly upregulated and correlated with Aβ since the early disease stage, but their roles in disease progression are not fully understood. Here we present that MDK attenuates Aβ assembly and influences amyloid formation in the 5xFAD amyloidosis mouse mod...

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Literature Corpus work: a0ae5b52-515e-52b5-8908-832f99495fdc
DOI: 10.21203/rs.3.rs-4361125/v1

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