Article

APP substrate ectodomain defines Aβ length by restraining γ-secretase processivity and facilitating product release

2023-09-13

Abstract excerpt

Sequential proteolysis of the amyloid precursor protein (APP) by γ-secretases (GSECs) generates amyloid-β (Aβ) and defines the proportion of short-to-long Aβ peptides, which is tightly connected to Alzheimer’s disease (AD) pathogenesis. Here, we study the mechanism controlling substrate processing by GSECs and defining product length. We found that polar interactions established by the APP C99 ectodomain (ECD), i...

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Literature Corpus work: e0ab19d8-8fec-5e2f-94bc-d2273aaa3fb2
DOI: 10.1101/2023.09.13.557360

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