Article

Probing tau citrullination in Alzheimer’s disease brains and mouse models of tauopathy

2024-07-09

Abstract excerpt

Tauopathies, which include Alzheimer’s disease (AD) share a common defining factor, namely misfolded tau protein. However, the “upstream” etiology and downstream clinical manifestations of tauopathies are quite diverse. Tau deposition elicits different pathological phenotypes and outcomes depending on the tau strain and regional susceptibility. Posttranslational modifications (PTM) can alter tau structure, functio...

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Literature Corpus work: 121c6ca6-6e87-5c2c-b175-817022261845
DOI: 10.1101/2024.07.06.601399

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