Article

Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

2022-07-21

Abstract excerpt

<h4>Background: </h4> Aggregation of the amyloid-b (Ab) peptide in the brain is one of the key pathological events in Alzheimer’s disease (AD). Reducing Ab levels in the brain by enhancing its degradation is one of the important strategies to develop new therapies for AD. Neprilysin (NEP) is a membrane bound metallopeptidase and one of the major Ab-degrading enzymes. The secreted soluble form of NEP (sNEP) has bee...

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Literature Corpus work: 0e782f1f-1ff9-5812-9631-3d9267a11a8d
DOI: 10.21203/rs.3.rs-1854452/v1

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