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Article

Dispatched uses Na+ flux to power release of lipid-modified Hedgehog.

Nature - 1 Nov 2021

Wang Qianqian, Asarnow Daniel E, Ding Ke, Mann Randall K, Hatakeyama Jason, Zhang Yunxiao, Ma Yong, Cheng Yifan, Beachy Philip A

Abstract excerpt

The Dispatched protein, which is related to the NPC1 and PTCH1 cholesterol transporters1,2 and to H+-driven transporters of the RND family3,4, enables tissue-patterning activity of the lipid-modified Hedgehog protein by releasing it from tightly -localized sites of embryonic expression5-10. Here we determine a cryo-electron microscopy structure of the mouse protein Dispatched homologue 1 (DISP1), revealing three...

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Identifiers

PMID: 34707294
DOI: 10.1038/s41586-021-03996-0
PMCID: PMC8785653

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