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Article

Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release.

Nature communications - 29 Nov 2021

Li Wanqiu, Wang Linlin, Wierbowski Bradley M, Lu Mo, Dong Feitong, Liu Wenchen, Li Sisi, Wang Peiyi, Salic Adrian, Gong Xin

Abstract excerpt

The membrane protein Dispatched (Disp), which belongs to the RND family of small molecule transporters, is essential for Hedgehog (Hh) signaling, by catalyzing the extracellular release of palmitate- and cholesterol-modified Hh ligands from producing cells. Disp function requires Furin-mediated proteolytic cleavage of its extracellular domain, but how this activates Disp remains obscure. Here, we employ...

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Identifiers

PMID: 34845226
DOI: 10.1038/s41467-021-27257-w
PMCID: PMC8630017

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