Article

Region-specific generation and retention of acetylated cohesin shape the genome-wide pattern of sister chromatid cohesion

2026-01-15

Abstract excerpt

Sister chromatid cohesion depends on ESCO2-mediated acetylation of the cohesin subunit SMC3, yet how this modification is established and maintained across the genome remains poorly understood. Here, we examined the chromatin-binding dynamics of ESCO2 and its enzymatic activity using quantitative ChIP-seq of human cells synchronously progressing through S phase. ESCO2 bound broadly along chromosomes without formin...

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Literature Corpus work: cdd8ad67-acd7-5817-8b97-85c4a2179162
DOI: 10.64898/2026.01.14.699591

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