Article

Neuronal Population Models Reveal Specific Linear Conductance Controllers Sufficient to Rescue Preclinical Disease Phenotypes

2020-06-02

Abstract excerpt

<h4>Objective</h4> During the preclinical phase of drug development, potential drug candidates are often screened for their ability to alleviate certain in vitro electrophysiological features among neurons. This ability is assessed by measuring treatment outcomes using the population mean, both across different cells and different animals. The go/no-go decision for progressing a drug to a clinical trial is then...

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Literature Corpus work: 2aa272f1-234e-5d69-bcfa-033ab07a76c0
DOI: 10.1101/2020.06.01.128033

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