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Article

All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS.

Stem cell reports - 5 Jun 2018

Kiskinis Evangelos, Kralj Joel M, Zou Peng, Weinstein Eli N, Zhang Hongkang, Tsioras Konstantinos, Wiskow Ole, Ortega J Alberto, Eggan Kevin, Cohen Adam E

Abstract excerpt

Human induced pluripotent stem cell (iPSC)-derived neurons are an attractive substrate for modeling disease, yet the heterogeneity of these cultures presents a challenge for functional characterization by manual patch-clamp electrophysiology. Here, we describe an optimized all-optical electrophysiology, "Optopatch," pipeline for high-throughput functional characterization of human iPSC-derived neuronal cultures....

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PMID: 29779896
DOI: 10.1016/j.stemcr.2018.04.020
PMCID: PMC5993648

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SOD1

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