Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.

doi:10.1038/s41598-017-17378-y

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Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.

Scientific reports - 19 Dec 2017

Pei Fen, Li Hongchun, Henderson Mark J, Titus Steven A, Jadhav Ajit, Simeonov Anton, Cobanoglu Murat Can, Mousavi Seyed H, Shun Tongying, McDermott Lee, Iyer Prema, Fioravanti Michael, Carlisle Diane, Friedlander Robert M, Bahar Ivet, Taylor D Lansing, Lezon Timothy R, Stern Andrew M, Schurdak Mark E

Abstract excerpt

Quantitative Systems Pharmacology (QSP) is a drug discovery approach that integrates computational and experimental methods in an iterative way to gain a comprehensive, unbiased understanding of disease processes to inform effective therapeutic strategies. We report the implementation of QSP to Huntington's Disease, with the application of a chemogenomics platform to identify strategies to protect neuronal cells...

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PMID: 29259176
DOI: 10.1038/s41598-017-17378-y
PMCID: PMC5736652

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