Population-based mechanistic modeling allows for quantitative predictions of drug responses across cell types

Abstract excerpt

<h4>ABSTRACT</h4> Quantitative mismatches between human physiology and experimental models can present serious limitations for the development of effective therapeutics. We addressed this issue, in the context of cardiac electrophysiology, through mechanistic mathematical modeling combined with statistical analyses. Physiological metrics were simulated in heterogeneous populations describing cardiac myocytes from...

Topics

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• Action Potentials
• Arrhythmias, Cardiac
• Cardiac Conduction System Disease
• Computer Simulation
• Induced Pluripotent Stem Cells
• Information Storage and Retrieval
• Myocytes, Cardiac
• Phenotype

Identifiers and source

Literature Corpus work

915e1acb-1093-59b8-a333-aaaaee72db00

DOI

10.1101/176321