Article

The NaaS Methodology applied to modeling chemotherapy-induced peripheral neuropathy with human hiPSC neurons

2025-09-28

Abstract excerpt

The Neuron-as-a-Sensor (NaaS) methodology is a human-relevant platform designed to detect compound-induced effects by capturing functional changes in neuronal activity. This is achieved by integrating hiPSC-derived neuronal cultures, compartmentalized MEA microfluidic devices, a detailed electrophysiology paradigm and a standardized analysis pipeline. Applied to chemotherapy-induced peripheral neuropathy (CIPN), N...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a7905a98-aedb-5b40-aa0d-fe1487919579
DOI: 10.1101/2025.09.25.678500

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The NaaS Methodology applied to modeling chemotherapy-induced peripheral neuropathy with human hiPSC neuronsDOI 10.1101/2025.09.25.678500Read

Human Peripheral Nerve-on-a-Chip on a Multiwell Microelectrode Array as a Scalable Preclinical Neurotoxicity AssaySemantic proximity Read

Profiling Human iPSC-Derived Sensory Neurons for Analgesic Drug Screening Using a Multi-Electrode ArraySemantic proximity Read

Phenotypic Screening of Prospective Analgesics Among FDA-Approved Compounds using an iPSC-Based Model of Acute and Chronic Inflammatory Nociception.Semantic proximity Read

Generation of human nociceptor-enriched sensory neurons for the study of pain-related dysfunctionsSemantic proximity Read

Plate-Based Phenotypic Screening for Pain Using Human iPSC-Derived Sensory Neurons.Semantic proximity Read

A high-content platform for physiological profiling and unbiased classification of individual neuronsSemantic proximity Read

Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of PaclitaxelSemantic proximity Read

Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of PaclitaxelSemantic proximity Read

Development of a multi-sensor integrated midbrain organoid-on-a-chip platform for studying Parkinson’s diseaseSemantic proximity Read

Human neuronal networks on micro-electrode arrays are a highly robust tool to study disease-specific genotype-phenotype correlations <i>in vitro</i>Semantic proximity Read

Modeling chemotherapeutic neurotoxicity with human induced pluripotent stem cell-derived neuronal cells.Semantic proximity Read

Targeting strategies for oxaliplatin-induced peripheral neuropathy: clinical syndrome, molecular basis, and drug development.Semantic proximity Read