Article

All-optical electrophysiology for high-throughput functional characterization of human iPSC-derived motor neuron model of ALS

2018-03-27

Abstract excerpt

Human induced pluripotent stem cell (iPSC)-derived neurons are an attractive substrate for modeling disease, yet the heterogeneity of these cultures presents a challenge for functional characterization by manual patch clamp electrophysiology. Here we describe an optimized all-optical electrophysiology, “Optopatch”, pipeline for high-throughput functional characterization of human iPSC-derived neuronal cultures. We...

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Identifiers and source

Literature Corpus work: 95f63073-062f-5dfc-b57f-a2d6d19edc27
DOI: 10.1101/289959

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