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Article

Understanding responder neurobiology in schizophrenia using a quantitative systems pharmacology model: application to iloperidone.

Journal of psychopharmacology (Oxford, England) - 1 Apr 2015

Geerts Hugo, Roberts Patrick, Spiros Athan, Potkin Steven

Abstract excerpt

The concept of targeted therapies remains a holy grail for the pharmaceutical drug industry for identifying responder populations or new drug targets. Here we provide quantitative systems pharmacology as an alternative to the more traditional approach of retrospective responder pharmacogenomics analysis and applied this to the case of iloperidone in schizophrenia. This approach implements the actual...

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Identifiers

PMID: 25691503
DOI: 10.1177/0269881114568042

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GRIA4

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