Article

Efficient Generation and Selection of Virtual Populations in Quantitative Systems Pharmacology Models

2015-10-06

Abstract excerpt

Quantitative systems pharmacology models mechanistically describe a biological system and the effect of drug treatment on system behavior. Because these models rarely are identifiable from the available data, the uncertainty in physiological parameters may be sampled to create alternative parameterizations of the model, sometimes termed ‘Virtual Patients.’ In order to reproduce the statistics of a clinical populat...

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Literature Corpus work: 01a5d956-0a54-5fd4-a4e4-e5aebb6e2f30
DOI: 10.1101/028548

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