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All-Optical Electrophysiology Refines Populations of In Silico Human iPSC-CMs for Drug Evaluation

4 Apr 2020

Abstract excerpt

transients (CaTrs). Parallel computational advances have shown that in silico simulations can predict drug effects with high accuracy. We combine these in vitro and in silico technologies and demonstrate the utility of high-throughput experimental data to refine in silico hiPSC-CM populations and to predict and explain drug action mechanisms. Optically obtained hiPSC-CM APs and CaTrs were used from spontaneous...

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PMID: 32298635
DOI: 10.1016/j.bpj.2020.03.018

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