Article

Flow-cell based technology for massively parallel characterization of base-modified DNA aptamers

2020-04-27

Abstract excerpt

Aptamers incorporating chemically modified bases can achieve superior affinity and specificity compared to natural aptamers, but their characterization remains a labor-intensive, low-throughput task. Here we describe the ‘non-natural aptamer array’ (N2A2) system, in which a minimally modified Illumina MiSeq instrument is used for the high-throughput generation and characterization of large libraries (∼10 6 ) of b...

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Literature Corpus work: c7a4da63-c37c-5cff-9c98-b93f632545a7
DOI: 10.1101/2020.04.25.060004

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