Article

Complementary 2D and 3D cultures deriving from a single human cortical differentiation process recapitulate in vitro neurodevelopmental and neurogenerative features of juvenile Huntington’s Disease

2026-07-17

Abstract excerpt

<title>Abstract</title> <p>The development of reliable human-based models that accurately recapitulate the pathophysiology of neurological disorders remains a major challenge in translational research. Human induced pluripotent stem cells (iPSCs) have emerged as a powerful tool to overcome the limitations of animal models, enabling the generation of disease-relevant cell types. While both two-dimensional (2D) neu...

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Literature Corpus work: 0e7e4fbd-361a-571b-8211-b5c7fc608678
DOI: 10.21203/rs.3.rs-10092322/v1

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Complementary 2D and 3D cultures deriving from a single human cortical differentiation process recapitulate in vitro neurodevelopmental and neurogenerative features of juvenile Huntington’s DiseaseDOI 10.21203/rs.3.rs-10092322/v1Read

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