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Article

Endogenous mutant Huntingtin alters the corticogenesis via lowering Golgi recruiting ARF1 in cortical organoid.

Molecular psychiatry - 1 Oct 2024

Liu Yang, Chen Xinyu, Ma Yunlong, Song Chenyun, Ma Jixin, Chen Cheng, Su Jianzhong, Ma Lixiang, Saiyin Hexige

Abstract excerpt

Pathogenic mutant huntingtin (mHTT) infiltrates the adult Huntington's disease (HD) brain and impairs fetal corticogenesis. However, most HD animal models rarely recapitulate neuroanatomical alterations in adult HD and developing brains. Thus, the human cortical organoid (hCO) is an alternative approach to decode mHTT pathogenesis precisely during human corticogenesis. Here, we replicated the altered...

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Source

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Identifiers

PMID: 38654124
DOI: 10.1038/s41380-024-02562-0
PMCID: PMC11449793

Genes

ARF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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