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Article

Huntington's disease cellular phenotypes are rescued non-cell autonomously by healthy cells in mosaic telencephalic organoids.

Nature communications - 2 Aug 2024

Galimberti Maura, Nucera Maria R, Bocchi Vittoria D, Conforti Paola, Vezzoli Elena, Cereda Matteo, Maffezzini Camilla, Iennaco Raffaele, Scolz Andrea, Falqui Andrea, Cordiglieri Chiara, Cremona Martina, Espuny-Camacho Ira, Faedo Andrea, Felsenfeld Dan P, Vogt Thomas F, Ranzani Valeria, Zuccato Chiara, Besusso Dario, Cattaneo Elena

Abstract excerpt

Huntington's disease (HD) causes selective degeneration of striatal and cortical neurons, resulting in cell mosaicism of coexisting still functional and dysfunctional cells. The impact of non-cell autonomous mechanisms between these cellular states is poorly understood. Here we generated telencephalic organoids with healthy or HD cells, grown separately or as mosaics of the two genotypes. Single-cell RNA...

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Identifiers

PMID: 39095390
DOI: 10.1038/s41467-024-50877-x
PMCID: PMC11297310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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