Article

Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction

2019-06-03

Abstract excerpt

<h4>ABSTRACT</h4> Although the underlying neurobiology of major mental illness (MMI) remains unknown, emerging evidence implicates a role for oligodendrocyte-myelin abnormalities. Here, we took advantage of a large family carrying a balanced t(1;11) translocation, which substantially increases risk of MMI, to undertake both diffusion tensor imaging (DTI) and cellular studies to evaluate the consequences of the t(...

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Literature Corpus work: 3d7b7d5d-620f-52a5-8179-d34dc20de13d
DOI: 10.1101/657163

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