Article
Targeting BET Bromodomains in Cancer
2022-01-18
Abstract excerpt
Cancer is frequently dependent on aberrant gene expression programs that might be vulnerable to targeting with novel therapeutics. Bromodomain and extraterminal domain (BET) proteins are powerful transcriptional coregulators often found as part of oncogenic transcriptional programs. The bromodomain functionality of BET proteins is highly druggable, and several product candidates are in clinical testing. While init...
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Identifiers and source
- Literature Corpus work
- 7e3a52a1-e583-519f-93dd-601f3e1985e2
- DOI
- 10.1146/annurev-cancerbio-070120-103531