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Article

Pitx2 impairs calcium handling in a dose-dependent manner by modulating Wnt signalling

4 Aug 2015

Abstract excerpt

AIMS: Atrial fibrillation (AF) is the most common type of arrhythmia in humans, yet the genetic cause of AF remains elusive. Genome-wide association studies (GWASs) have reported risk variants in four distinct genetic loci, and more recently, a meta-GWAS has further implicated six new loci in AF. However, the functional role of these AF GWAS-related genes in AF and their inter-relationship remain elusive. METHODS...

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PMID: 26243430
DOI: 10.1093/cvr/cvv207

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