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Article

Homeobox transcription factor Pitx2: The rise of an asymmetry gene in cardiogenesis and arrhythmogenesis.

Trends in cardiovascular medicine - 1 Jan 2014

Franco Diego, Christoffels Vincent M, Campione Marina

Abstract excerpt

The homeobox transcription factor Pitx2 displays a highly specific expression pattern during embryogenesis. Gain and loss of function experiments have unraveled its pivotal role in left-right signaling. Conditional deletion in mice has demonstrated a complex and intricate role for Pitx2 in distinct aspects of cardiac development and more recently a link to atrial fibrillation has been proposed based on...

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Source

Identifiers

PMID: 23953978
DOI: 10.1016/j.tcm.2013.06.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Homeobox transcription factor Pitx2: The rise of an asymmetry gene in cardiogenesis and arrhythmogenesis.PMID 23953978Read ↗

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<i>Pitx2</i> prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specificationSemantic proximity Read ↗

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<i>PITX2</i> Insufficiency Leads to Atrial Electrical and Structural Remodeling Linked to ArrhythmogenesisSemantic proximity Read ↗

A cellular atlas of <i>Pitx2-</i>dependent cardiac developmentSemantic proximity Read ↗

Ventricular chamber-specific Pitx2 insufficiency leads to cardiac hypertrophy and arrhythmiasSemantic proximity Read ↗

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The Long Noncoding RNA <i>Playrr</i> Regulates <i>Pitx2</i> Dosage and Protects Against Cardiac ArrhythmiasSemantic proximity Read ↗

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