Article

The Long Noncoding RNA <i>Playrr</i> Regulates <i>Pitx2</i> Dosage and Protects Against Cardiac Arrhythmias

2022-09-20

Abstract excerpt

<h4>Rationale</h4> The most significantly associated atrial fibrillation (AF) risk loci in humans map to a noncoding gene desert upstream of the evolutionarily conserved left-right (LR) transcription factor Pitx2 , a master regulator of LR asymmetric organ development. Pitx2 dosage is fundamentally linked to the development of sinus node dysfunction (SND) and AF, the most common cardiac arrhythmia affecting adu...

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Literature Corpus work: 0ad38fcb-d4df-5632-a4ca-fe955adf7114
DOI: 10.1101/2022.09.20.508562

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