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Article

Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 2014

Wang Jun, Bai Yan, Li Na, Ye Wenduo, Zhang Min, Greene Stephanie B, Tao Ye, Chen Yiping, Wehrens Xander H T, Martin James F

Abstract excerpt

The molecular mechanisms underlying atrial fibrillation, the most common sustained cardiac arrhythmia, remain poorly understood. Genome-wide association studies uncovered a major atrial fibrillation susceptibility locus on human chromosome 4q25 in close proximity to the paired-like homeodomain transcription factor 2 (Pitx2) homeobox gene. Pitx2, a target of the left-sided Nodal signaling pathway that initiates...

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Identifiers

PMID: 24927531
DOI: 10.1073/pnas.1405411111
PMCID: PMC4078868

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation.PMID 24927531Read ↗

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