Article

Remodeling of <i>Il4-Il13-Il5</i> locus underlies selective gene expression

2022-07-22

Abstract excerpt

The type 2 cytokines, interleukin (IL)-4, IL-5 and IL-13 reside within a tandem multi-gene cluster in mammals. These cytokines represent the hallmark of type 2 immune responses controlling parasites, promoting tissue repair as well as causing allergic diseases. Both innate and adaptive lymphocytes secrete type 2 cytokines with discordant production spectra. We took a holistic structural and functional view of the...

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Literature Corpus work: 2a5c217f-4a91-5220-8206-ac879db6b59f
DOI: 10.1101/2022.07.22.501024

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