Article

Common γ-chain cytokines induce an epigenomically plastic precursor-like KIT <sup>+</sup> ILC2 state linked to immune disease susceptibility

2026-03-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Group 2 innate lymphoid cells (ILC2s) are key effector cells of type-2 immunity. A subset of ILC2s expresses KIT (CD117), which display increased phenotypic plasticity and were previously linked to severe asthma and psoriasis. However, the molecular mechanisms promoting a KIT + ILC2 state remain poorly understood. <h4>Objective</h4> Define the molecular basis for the enha...

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Literature Corpus work: b7cfb1a9-2c7c-5c9e-8e65-dd1b469b7db0
DOI: 10.64898/2026.02.27.708582

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