Article

Dissecting surveying behavior of reactive microglia under chronic neurodegeneration

2025-06-05

Abstract excerpt

In the healthy brain, microglia maintain homeostasis by continuously surveying neuronal health through highly dynamic processes that form purinergic junctions with neuronal somas. These mechanisms are finely tuned for the rapid detection of acute injuries. However, during the transition to a chronically reactive state in neurodegenerative diseases, microglial ramification decreases even as the need for neuronal mo...

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Literature Corpus work: 2a557115-b61a-501b-afa3-c52be275a165
DOI: 10.1101/2025.06.02.657382

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