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Article

APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12.

Molecular neurodegeneration - 11 Mar 2024

Sepulveda Jordy, Kim Jennifer Yejean, Binder Joseph, Vicini Stefano, Rebeck G William

Abstract excerpt

Microglia are highly dynamic cells that play a critical role in tissue homeostasis through the surveillance of brain parenchyma and response to cues associated with damage. Aging and APOE4 genotype are the strongest risk factors for Alzheimer's disease (AD), but how they affect microglial dynamics remains unclear. Using ex vivo confocal microscopy, we analyzed microglial dynamic behaviors in the entorhinal cortex...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 38468308
DOI: 10.1186/s13024-024-00714-y
PMCID: PMC10929239

Genes

P2RY12
APOE
CA1
CX3CR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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